THE EFFECT OF FLUOXETINE AND AMITRIPTYLINE ON CARDIOMYOCYTES OF ALBINO RAT : A COMPARATIVE HISTOCHEMICAL AND ULTRASTRUCTURAL STUDY
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ABSTRACT This study was done to evaluate and compare the toxic potentialities of fluoxetine and Amitriptyline on cardiomyocytes of albino rats. 30 male albino rats weighing 200-250 grams were divided into 3 groups: • Group (1) : Received fluoxetine once daily at dose of 45mg/kg b.w for one month. • Group (2) : Received Amitriptyline once daily at dose of 38 mg/kg b.w for one month. • Group (3) : (Control) received distilled water once daily for the same period. Histochemically : Fluoxetine-treated group showed slight decrease of ATPase and succinic dehydrogenase activities of cardiac muscle while Amitriptyline caused marked decrease of ATPase and succinic dehydrogenase activities. Ultrastructural examination : Showed that fluoxetine caused significant mitochondrial damage in atrial cardiomyocytes while Amitriptyline caused significant severe mitochondrial damage in atrial and ventricular cardiomyocytes.