Publications of Faculty of Medicine:Triphasic Spiral CT in Hepatocellular Carcinoma Timing Optimization for Increasing Detectability: Abstract

Triphasic Spiral CT in Hepatocellular Carcinoma Timing Optimization for Increasing Detectability
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The role of CT imaging in detection of hepatocellular carcinoma is well established and many strategies for optimizing data acquisition to improve CT detection of HCC were tried. Helical CT is an ideal method that fulfills the requirements of rapid scanning during the short interval of maximum hepatic enhancement. The aim of this work was to establish the optimal protocol for contrast injection and image acquisition to achieve maximum liver to tumor contrast in cases of HCC. Thirty-five patients with pathologically proven HCC were examined by triphasic spiral CT of the liver; they were divided into two groups, utilizing a different injection protocol in each group. It was found that 97.9% of the lesions were detected during arterial phase in both groups, while 85% of the lesions were seen in delayed phase and only 68% were detected in portal venous phase. It was also noted that maximal tumor enhancement occurs at a longer delay time and a higher rate of contrast injection. We concluded that in dynamic helical CT of the liver, high injection rate and short delay time provide higher and faster enhancement of the hepatocellular carcinoma and hence increase lesion detectability. Key Words: Triphasic spiral CT - Hepatocellular carcino