THE EFFECT OF HYPERGLYCEMIA ON SERUM TRANSFORMING GROWTH FACTOR-B1 (TGF-B1) LEVEL AND THEIR RELATIONS TO DIABETIC NEPHROPATHY IN PATIENTS WITH CONTROLLED TYPE 2 DIABETES MELLITUS
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TGF-fil plays a critical role in the pathogenesis of different types of nephropathy. The current work aimed at investigating the effects of hyperglycemia on serum 7UF-131 to clarifr their relations to diabetic nephropathy in controlled type 2 diabetic patients.Fourty-eight patients were categorized according to the concentration of urinary microalbumin per 241t into normoalbuminuric, microalbuminuric and macroalbuminuric groups. Each group comprised 16 patients of both sex. Their age ranged from 42 to 75 years, with a mean value of 57.9±.9.1 years. These patients were compared to 10 healthy subjects, age and sex matched who served as controls. The results of the present work showed that; the mean values of serum TGF-fl 1 in normoalbuminuric, microalbuminuric and macroalbuminuric groups were significantly elevated compared to the control group (p<0.05). Also, diabetic patients with nephropathy showed that; the mean values of serum TGF-13.1 in hypertensives were signifkcmtly elevated compared to normotensive patients (p<0.05). Furthermore, gender had non-significant effect on serum TGF-I31. Moreover, correlation study showed a significant positive correlation between urinary microalbumin per 24h and serum TGF-I31 in microalbuminuric and macroalbuminuric (p<0.05) groups. In addition, systolic and diastolic blood pressure showed significant positive correlation with serum TGF-/31 in macroalbuminuric group (p<0.05). The results of this work showed that; the augmented effects of hyperglycemia and the subsequent increase in serum TGFfil could play a prominent role in the pathogenesis of diabetic nephropathy. This nzay be helpful when using TGF-I31 system as a new therapeutic target for treatment and prevention of diabetic nephropathy in the future.