THE PERCENTAGE OF LOW SERUM B12 AND FOLATE AFFECT SERUM TOTAL HOMOCYSTEINE LEVEL IN EGYPTIAN WOMEN WITH RECURRENT MISCARRIAGE
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The current study was aimed to find out the percentage of low serum BI2 and folate and their interactions with serum total homocysteine level in Egyptian women experiencing unexplained recurrent miscarriage. A total of 50 women were studied for determination of serum B12, folate and total homocysteine, of them 20 women were primary aborters and 15 women were secondary aborters and 15 healthy women who served as controls. Their age ranged from 19-40 years with the mean value 30.5 years . The results of this work showed significant differences between the percentage of those with low serum B12 and folate in primary, secondary and all aborters compared with the control group (p<0.05). Also, the percentage of those with high serum homocysteine showed a significant difference in primary and all aborters but not in secondary aborters when compared with the control group. On the other hand, the mean values of serum BIZ folate and homocysteine showed signcant differences in all women with recurrent miscarriage compared with the control group (p<0.05). Statistical correlation showed significant negative correlation between serum folate and total homocysteine in primary aborters(r= -0.449 p<0.05). We could conclude that; there were an interaction between deficiencies of B12 and folate with hyperhomocysteinemia which may contribute to the etiology of unexplained recurrent early pregnancy loss. Identification of those women with hyperhomocysteinemia may be of help in therapeutic normalization and might permit a normal birth.