The Extra-gastric Effects of Chronic Helicobacter Pylori Infection in Dyspeptic patients on Some Metabolic Risk Factors For Coronary Heart Disease
|Full paper||Not Available|
Hyperlipidemia. thrombophilia and hyperhomocysteinemia were all known metabolic risk factors for coronary heart disease. The association between the extra-gastric effects of chronic helicobacter pylori (h.pylori) infection arid these risk factors in dyspeptic patients needs to be clarified. Forty subjects were studied for determination of serum total cholesterol, triglycerides, very low density lipoprotein-cholesterol (VLDL-c), low density lipoproteincholesterol (LDL-c), high density lipoprotein-cholesterol (HDL-c), plasma clotting factors VII, X. XII activities, fibrinogen concentration, antithrombin III (ATIII) activity as well as plasma total homocysteine. They were 26 males and 14 females. Their age ranged from 31 to 41, with a mean value of 35.8±2.6 years. They were categorized according to the concentration of h.pylori antibodies (IgG) into 15 patients who were seronegative and another 15 patients who were seropositive. These patients were compared with 10 healthy subjects, age and sex matched who served as controls. The results of the present work showed that; serum lipid profile had no significant differences in seronegative and seropositive patients for h.pylori infection compared with the control group (p>0.05). Moreover, plasma clotting factors VII, X, XII had no significant changes while plasma fibrinogen concentration and total homocysteine were significantly higher in seropositive compared with both seronegative patients and the control group (p<0.05). Additionally. seropositivity correlated significantly with plasma fibrinogen concentration (r=0.76 ; p<0.05). It could be concluded that, alteration of plasma fibrinogen and total homocysteine might be considered metabolic risk factors for coronary heart disease in dyspeptic patients due to Chronic h.pylori infection.