THE EFFECT OF CARVEDILOL ON POST-ISCHEMIC SPLANCHNIC TISSUE INJURY
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The objective of the current work aimed to investigate whether carvedilol is an effective antishock agent in the well established in vivo ischemia/ reperfusion model of splanchnic artery occlusion shock Also, to Investigate the mechanism of this protection, such as antioxidant properties, preservation of endothelial function, and inhibition of neutrophil accumulation and adhesion. For this study, 36 rats weighing 120- 200gm were selected They were classified into 4 groups; control, splanchnic ischemia-reperfusion (SYR), SI/R rats injected by O. 5 mg/kg carvedilol and SYR rats injected by 1.0 mg/kg carvedilot Each group was formed of 9 rats. The results obtained showed that; hematocrite, tissue malondialdehyde (MDA), and tissue myeloperoxidase (MPO) were sig-nificantly increased (P<0.001) while plasma MDA and anti MPO were non-significantly increased in ischemic-reperfusion group compared with the control group. Comparative study of injected groups versus noninjected STIR group, the result showed that; significant decrease of hematocrite (p<0.01), tissue MDA- (P<0.001) and MPO (p<0.001) while plasma MDA and anti MPO were non-significantly changed in SYR rats injected with 1.0 mg/Kg carvedilol. Mean while, SYR rats injected with 0.5mg/Kg carvedilol showed non significant changes of all studied biochemical parameters when compared with the non-injected SYR rats. We could conclude that; carvedilol pretreatment leads to amelioration of the adverse effects of SYR shock by scavenging oxygen five radicals, counteracting the increased microvascular permeability and inhibiting the adhesion and activation of neutrophils in this model of splanchnic ischemia/ reperfusion.