The objective of the current work aimed to investigate whether carvedilol
is an effective antishock agent in the well established in vivo ischemia/
reperfusion model of splanchnic artery occlusion shock Also, to Investigate
the mechanism of this protection, such as antioxidant
properties, preservation of endothelial function, and inhibition of neutrophil
accumulation and adhesion. For this study, 36 rats weighing 120-
200gm were selected They were classified into 4 groups; control,
splanchnic ischemia-reperfusion (SYR), SI/R rats injected by O. 5 mg/kg
carvedilol and SYR rats injected by 1.0 mg/kg carvedilot Each group
was formed of 9 rats. The results obtained showed that; hematocrite, tissue
malondialdehyde (MDA), and tissue myeloperoxidase (MPO) were
sig-nificantly increased (P<0.001) while plasma MDA and anti MPO were
non-significantly increased in ischemic-reperfusion group compared with
the control group. Comparative study of injected groups versus noninjected
STIR group, the result showed that; significant decrease of hematocrite
(p<0.01), tissue MDA- (P<0.001) and MPO (p<0.001) while plasma
MDA and anti MPO were non-significantly changed in SYR rats injected
with 1.0 mg/Kg carvedilol. Mean while, SYR rats injected with 0.5mg/Kg
carvedilol showed non significant changes of all studied biochemical parameters
when compared with the non-injected SYR rats.
We could conclude that; carvedilol pretreatment leads to amelioration
of the adverse effects of SYR shock by scavenging oxygen five radicals,
counteracting the increased microvascular permeability and inhibiting the
adhesion and activation of neutrophils in this model of splanchnic ischemia/
reperfusion. |
