Prospective Study on The Effect of Normal Dose and Overdose of Nigella Sativa Linnaeus (Black Seeds) on Some Biochemical Parameters in Rats
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Lipid profile, serum total cholesterol (T. C)., triglycerides(T.G). very low density lipoproteins cholesterol (VLDLc)., low density lipoproteins cholesterol (LDLc), high density lipoproteins cholesterol (HDLc) and HDLc / LDLc ratio, liver and kidney functions, y-globulin were estimated in 37 male rats that were included into 3 groups: control group (10), 12 rat were taken normal dose Nigella sativa (40 mg/kg/day for ten days), 15 rat were taken overdose Nigella (ten times normal dose for ten days). In normal dose group, there was significant decrease (P < 0.02) in lipid profile except HDLc and HDLc/ LDLc ratio where significant increase (P <0.001) than control group was noticed. In overdose group, there was significant (P <0.01) increase in T.C. and HDLc than control group. Moreover, there was significant increase in lipid profile (P < 0.001) than normal dose group. As regard liver, kidney functions and y-globulin, in normal dose Nigella sativa there were significant (P < 0.05) decrease in serum bilirubin and serum aspartate transaminase (ASP but, significant (P <0.05) increase in y-globulin. Finally, we concluded tnat Nigella sativa in normal dose and overdose had a very important beneficial effect on lipid profile, liver, kidney functions and immunity.