DIAGNOSTIC AND PROGNOSTIC VALUE OF SOME BIOCHEMICAL MARKERS IN MENINGITIC CEREBROSPINAL FLUID (CSF).
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Cerebrospinal fluid (CSF) samples were obtained from 30 cases with meningitis and 10 neurologically free controls. Twenty patients were diagnosed bacteriologically as: 10 aseptic and 10 septic meningitis. CSF samples were analysed for tumour necrosis factor-alpha (TNF-a), fatty acids (FA) (palmitic, stearic and palmitoleic acids), transferrin and albumin. The results showed that there were significant increases (P<0.0001) in the studied parameters in septic meningitis compared to control and aseptic meningitis. Palmitoleic fatty acid was only detected in septic meningitis. Therefore, determination of TNFa, fatty acids, albumin and transferrin in CSF may be a sensitive and rapid indicator of septic meningitis compared to microscopy and culture. They may also have a prognostic value as CSF albumin and transferrin can indicate impairment of blood brain barrier permeability and palmitic and stearic acids may be related to neurological disorders.