ANTIOXIDANT STATUS AND LIPID PEROXIDATION IN SUBJECTS WITH IMPAIRED GLUCOSE TOLERANCE (IGT)
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An imbalance in the antioxidant protective mechanism leading to oxidative stress has been shown in complicated non-insulin dependent diabetes (NIDDM) cases. This work has been conducted to assess the antioxidant activity in IGT which has received much attention as a risk factor for NIDDM. The lipid peroxide malondialdebyde • (MDA), a marker of free oxygen radical activity along with blood reduced glutathione and plasma selenium and vitamins C and E were measured in 27 cases with TOT. In addition, 2 age, sex and body mass index-matched groups were studied. They were 20 NIDDM eases with no detectable complications and 20 healthy normal controls with normal oral glucose tolerance. The 4 tested antioxidants were significantly decreased (p< 0.001) in MT and NIDDM subjects compared to control. Meanwhile, plasma MDA was significantly increased (p< 0.001) in each of IGT and NIDDM groups versus control. Changes were more evident in NIDDM cases but were unrelated to the state of glycemic control (fasting blood sugar and HbAlc) but can be associated partially to the duration of diabetes. In conclusion, the antioxidant status is poor IGT as well as early NIDDM cases. Antioxidant therapy worths trial in future studies as it might possibly delay progression of IGT to frank diabetes.