EFFECT OF ACUTE AND CHRONIC STRESS ON THE HEMOSTATIC BALANCE AND THE ROLE OF RENIN-ANGIOTENSIN SYSTEM
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Stress is involved in the development of diseases related to abnormal hemostasis. Thrombosis may develop whenever the dynamic balance between prothrombotic and antithrombotic processes become altered Recently, renirt aru3iotensin system is considered to be a stress hormone response system. The aim of the present work was to clarify the effect of acute and chronic stress on the prothrombotic and antithrombotic activity and to study the role of angiotensin II in these stress-induced changes. The results of this work showed that acute ether stress and chronic isolation stress lead to suppression of both intrinsic and extrinsic coagulability manifested by a decrease in the fibrinogen concentration and a decrease in the activity of factors VII and X, at the same time acute and chronic stress caused a decrease in the antithrombotic activity indicated by a reduction in the activity of antithrotnbin III. This means that hemostatic balance is probably maintained at a low level, this make it difficult to hypothesize the existence of a hypercoagulable or a hypocoagulable state during stress. These changes can not be attributed to hemodilution since we found that stress causes hemoconcentration indicated by increased packed cell volume. The results of this work showed, also, that, these stress-induced hemostatic changes was prevented by pretreatment with the angiotensirt converting enzyme inhibitor fperindopria this means that these stress-induced hemostatic changes is mediated, at least partially, through the renin angiotensin system.