ACUTE RESUSCITATION OF BURN INJURY: HAES-STERIL VERSUS LACTATED RINGER'S SOLUTION
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Thermal injuries cause many complications and deaths Most burned patients have reduced plasma volume and expanded interstitial water. Haes-S'teril is used for medium term expansive volume replacement therapy to achieve a more rapid and profound improvement of hemodynamic variables. The current study compared the effects of acute fluid therapy using lactated Ringer's. (LR) solution and Haes-Steril 10% on hemodynamic variables, volume oxygen consumption (1/02) and renal fitnction of burned patients. The study comprised 40 patients with burn greater than 15% of total body surface area (TBSA) allocated in two groups receiving either LR-sohttion or Hcres-Steril 10%. Comparison of results qf both studied groups showed a non-significant (P>0.05) difference with regard to heart rate. .(HR) and mean arterial blood pressure (MAP), but showed a significant (P<0.05) increase of central venous pressure (CVP), cardiac output ((VP,), cardiac index (CI) and V02, in patients included in Haes-group than in LR-group. Serum lactate, and plasma endothelin-1 (ET-I) levels were decreased in both groups en the end of study period, and showed negative significant correlation with increased CI. Serum creatinine was significantly decreased, and creatinine clearance rate was significantly increased in patients comprised in Hetes-group than in those included in LR-group. We can conclude that Haes-Steril 10% can improve overall hemodynamic situation of patients with burn and that serum creatinine can he used as ct predictive factor for improvement.