INSIGHT ON THE RELATION BETWEEN MATERNAL DERANGEMENT OF HOMOCYSTEINE METABOLISM AND THEIR OFFSPRINGS WITH CONTRUNCAL HEART DEFECTS
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This study was performed to evaluate the effect of maternal derangement of homocysteine (Heys) metabolism and their children with contruncal heart diseases. The fasting plasma levels of Heys, folk acid and vitamin 812 were measured by radioassay technique. The study consisted of 22 mothers of 22 offsprings having contruncal heart defects, (Pre-treatment group) and 20 healthy mothers having healthy offsprings as control group. Mothers having offspring with contruncal heart diseases administered a commercially available multivitamin supplementation, and considered as post-treatment group. The study revealed a mean fasting plasma Heys level, in pre-treatment group, of 13.17±2.63 mo1/1, and 11+1.81 p mal in post-treatment group and 9.71+1.63 p mo1/1 in control group, there was a statistically significant difference between all studied groups. Also, there was a positive significant correlation between maternal age and Heys plasma level, and a negative significant correlation between fasting plasma levels of Hcysand folate and vitamin 812. In conclusion, this study showed a significant increase of fasting plasma Heys level in mothers having offsprings with contruncal heart defects and that multivitamin supplementation would decrease this level.