LIPID PEROXIDATION PRODUCTS IN CHILDREN WITH LIVER DISEASES
|Full paper||Not Available|
We investigated variation in serum lipid peroxides (LPO) concentrations in relation to various clinical entities of liver diseases in children. Serum lipid peroxides were determined in 20 children with acute hepatitis, 14 with chronic hepatitis (4 chronic active and 10 chronic persistent hepatitis), 11 with liver cirrhosis, 7 with cholestasis and 20 children apparently healthy represented as a control group. Serum lipid peroxides levels were significantly (p < 0.001) increased in all patients groups when compared with the control group. Moreover, in patient group with acute hepatitis, it was significantly (p < 0.001) increased when compared with other patient groups, while there was no significant difference obtained between other groups of liver diseases. A significant correlation was found between serum lipid peroxides and a set of indices of hepatic function (serum total bilirubin "r = 0.616, p <0.05", serum direct bilirubin "r = 0.519, p < 0.05", ALT "r = 0.488, p = <0.05" and AST "r = 0.480, p < 0.05"). No significant correlation was obtained with other liver function (Alk. Ph. "r = 0.212, p > 0.05", GOT "r = 0.252, p > 0.05", serum proteins "r = 0.119, p > 0.05" or albumin "r = -0.111, p >0.05". In conclusion, serum levels of LPO increased in different groups of liver diseases especially acute hepatitis. It can be used as a marker for the intensity of inflammation rather than differentiation between different entities of liver disease.