Relation of 02-free radicals to some biochemical markers in patients with lung disease
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02-free radicals play a major role in the pathogenesis of many inflammatory conditions and malignancy. Also, sialic acid (Total & Lipid-Bound) were recorded to be disturbed in inflammation and malignancy. So, the aim of this work is to study the relationship between 02-free radicals, lipid-bound sialic acid (LSA), total sialic acid (TSA) and carcino-embryonic anitgen (CEA) in patients with chronic bronchitis & bronchogenic carcinoma. Also, to evaluate LSA TSA as Tumor markers in patients with bronchogenic carcinoma and assessed the individual and combined values of LSA, TSA, & CEA determination in these patients. To clarify this isssue, two groups of patients were studied. The first group included 20 patients with chronic bronchitis. Their age ranged from (44-58) years. The second group included another 20 patients with bronchogenic carcinoma. Their age ranged from (45-62). These groups of patients were compared with 10 healthy, age and sex matched as controls. The results of this study showed that; patients with chronic bronchitis and bronchogenic carcinoma have a significant increase of serum lipid peroxides (LP), LSA and TSA (P<0.00I) while serum CEA is significantly increased only in patients with bronchogenic carcinoma compared with the control group (P<0.001). Also, there was a significant positive correlation between serum LP and LSA (P<0.01), TSA (P<0.001) in patients with chronic bronchitis while, there was non-significant positive correlation with serum CEA. Also, there was a significant positive correlation between serum LP and LSA (P<0.001), TSA (P<0.001) and CEA (P<0.05) in patients with bronchogenic carcinoma. Serum LSA is more sensitive biochemical marker (80%) than TSA (75%) and serum CEA (60%) while serum CEA is more specific marker (73.3%) in diagnosis of patients with bronchogenic carcinoma than serum LSA (46.7%) and TSA (33.3%). We could conclude that, the increase of 02- free radicals may be the trigger for the increase of serum level of cell surface related sialoglycoprotein, sialoglycolipids, and tumor antigen (CEA). Neither one of the three biomarkers success to be absolutely diagnostic nor pathognomonic for bronchogenic carcinoma but, the combined measurement of LSA and CEA in serum may be helpful for better detection potential of bronchogenic carcinoma than either of the two markers alone So, we recommend to interpretate the results carefully in these group of patients to assure that inflammation or other benign conditions are not causing changes in the test values.