STUDY OF LIPID PATTERN AND SOME COAGULATION FACTORS IN IDDM WITH VARIABLE DEGREES OF ALBUMINURIA
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The aim of present study is to evaluate the abnormalities in concentrations of lipoproteins, apolipoprotein A1, and B, fibrinogen and clotting factor VII in insulin dependent diabetics with variable degrees of alb9minuria. This study included twenty healthy subjects as a control group (group I) in addition to sixty (60) insulin dependent diabetic patients. The diabetic patients were classified into: 20 diabetic patients with normoalbuminuria (group II), 20 diabetic patients with microalbuminuria (group III) and 20 diabetic patients with macroalbuminuria (group IV). Cholesterol, triglycerides, DDLc, LDLc, VLDLc, Apo-A1 , Apo-B, fibrinogen and factor VII activity were measured. There was a significant increase in serum cholesterol (P<0.001), serum LDLe (P<0.001), serum Apoprotein B, plasma fibrinogen (P<0.001) and factor VII activity (P<0.001) in 3 diabetic groups compared with the control group. In diabetic group with macroalbuminuria (group IV) compared with diabetic group with microalbuminuria, there was a significant increase (P<0.001) in serum VLDLc, serum triglycerides serum cholesterol plasma fibrinogen and plasma factor VII activity. We concluded that ApoB, LDL-c, fibrinogen and factor VII were more increased in both microalbuminuric and macroalbuminuric diabetic groups than normal control group, and these are related to increased risk for cardiovascular disease. Macroalbuminuric patients are more risky for cardiovascular diseases because most of these risk factors are higher than microalbuminuric group. This work may be of great clinical value in understanding the different mechanisms leading to macrovascular complications in insulin-dependent diabetics. Also, studying these abnormalities may be of great diagnostic and prognostic value and also may help us to plan preventive measures by trying to correct these abnormalities.