SERUM LEVELS OF SIALIC ACID AND GLYCOSAMINOGLYCANS IN ANKYLOSING SPONDYLMS
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The serum levels of sialic acid (SA) and glycosaminoglycans (GAGs) were measured in 16 patients with ankylosing spondylitis(AS)and their relationship with the disease activity was assessed. They were 12 males (75%) and 4 females (25 %). Their mean age was 32.3 ± 6.3 years and the mean duration of the disease was 7.1 ± 4 years. Another 13 healthy individuals matched for age and sex were chosen as a control group. All the patients were subjected to clinical assessment and laboratory investigations (ESR, CRP). The results showed significant increase in serum level of sialic acid with non significant change in serum glycosaminoglycans in ankylosing spondylitis compared to normal controls. Serum sialic acid correlated significantly with laboratory parameters of activity such as ESR, CRP and clinical parameters such as vertebral mobility, serum glycosaminglycans did not correlate with laboratory or clinical parameters of activity. From the previous results, it was found that serum sialic acid could be used as a parameter of activity in patients with ankylosing spondylitis.