GLUTATHIONE PEROXIDASE AND SELENIUM IN RHEUMATOID ARTHRITIS
|Full paper||Not Available|
The erythrocyte glutathione peroxidase (GP) level and the concentration of serum selenium were assessed in 20 patients with active rheumatoid arthritis and their correlation with the disease activity were studied. Mother 12 healthy persons, matched for age and sex were chosen as a control group. All the patients were subjected to clinical assessment and laboratory investigations, kinetic calorimetric assay showed a sty-war:int decrease of erythrocyte glutathione peroxidase level in patients with RA as compared to the controls. Also, atomic absorption spectrophotometric assay of serum selenium showed a significant decrease in the patients with RA as compared to the controls. Erythrocyte GP and serum selenium, showed a negative significant correlation with the parameters of the disease activity (morning stiffness, pain score, articular index and ESR.). From the previous results we could conclude that, the decreased glutathione peroxidase activity leads to the lack of antioxidative capacity of the glutathione peroxidase/ reductase system and this could have a pathogenic role in inflammation of rheumatoid arthritis.