SERUM LIPIDS AND LIPOPROTEIN PATTERN IN EGYPTIAN NEWBORNS
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Fourty neonates divided into three groups were included in the study; 15 normal fullterm, 14 preterm neonates and 11 infants of diabetic mothers. For each neonate, full clinical examinations, determination of gestational age and measurement of cord blood total serum cholesterol, high density lipoprotein-cholesterol(HDL-C), low density lipoprotein-cholesterol LDL-C) and apolipo-protein-B (apo-B) levels were performed. It was found that mean levels of cholesterol, IIDL-C, LDL-C and apo-B in the fullterm group lied in the expected normal range of variation. Their mean levels in the preterm group were significantly higher than in the fullterm group. In infants of diabetic mothers the mean levels of serum choelsterol, LDL-C and apo B were significantly higher than in fullterm neonates. There was sex difference in the levels of all determined lipids. Highly signficiant positive correlations between apo-B and LDL-C levels in all groups were found. It is concluded that preterm neonates and infants of diabetic mothers are at increased risk of early hyperlipidemia. We may suggest the application of apo-B quantitation as a valuable screening parameter for early detection of lipoprotein abnormalities.