The Effect Of Theophylline On Serum Erythropoietin In Premature Neonates And Older Children
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To study the effect of theophylline on erythropoietin, 4 groups were included in this work: group I (theophylline treated prematures), group II (theophylline untreated prematures for comparison), group III (theophylline treated children) and group IV (theophylline untreated children) for comparison. For all subjects, serum level of erythropoietin, hemoglobin concentration, red cell count, hematocrite value and serum level of theophylline (for treated subjects only) was estimated the beginning and at the end of the study. The results obtained showed a significant elevation in erythropoietin, Hb, RBCs and haematocrit values in group I as compared with group 11 as well as a significant decrease in erythropoietin level, Hb, RBCs and haematocrit value in group III as compared with group IV. It could be concluded that there is a discrepancy in the effect of theophylline therapy on serum erythropoietin level between prematures and older children This may be due to the altered tissue oxygenation seen in apnea of prematurity which may have a more potent stimulatory effect on erythropoietin production than does the depressant effect of theophylline in such population. Also, the effect of theophylline on erythropoietin production may change by age and thus may differ between prematures and older children.