Publications of Faculty of Medicine:THE IMPLICATION OF INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN-3 IN VARIOUS ARTHRITIDES: Abstract

Title:
THE IMPLICATION OF INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN-3 IN VARIOUS ARTHRITIDES
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Abstract:

the purpose of this study is to evaluate the role of insulin-like growth factor binding protein-3 (IGFB -3) in inflammatory and degenerative Joint diseases by estimating its level in the serum and synovial fluid of patients with Rheumatoid arthritis (RA) and Osteoarthritis (OA) and correlating these levels to the clinical features of these disorders. Twenty RA patients, twenty-eight OA patients and fourteen healthy controls were included in this study. All patients and controls were subjected to the following; full history, clinical examination, and laboratory investigation including TM, E'SR, estimation of the level of IGFBP-3 in both serum and novial lIzzid by radioimmunoassay procedure. Plain x-ray for both knees & ands was also included Patients with RA were divided according to their radiological findings into erosive and non erosive subgroups, and according to the mean disease activity grades (MDAG) into two groups, one including patients with MDAG1 & 2 and another including patients with MDAG3 & 4. OA patients were divided according to radiological findings into two subgroups, one including patients with grade 1 & II and another including grade HI & IV patients. And according to score of functional severity, we subgrouped OA patients into two subgroups; one including patients with score S.• 7 and another including patients with score 8. The present study showed no sig.ncant difference between the serum level of the IGFBP-3 of both RA and OA patients when compared to the controls. A significant increase (P < 0.05) was found in the synovial IGFBP-3 of RA patients when compared to the controls. No significant difference was found between synovial IGFBP-3 of OA patients when compared to the controls. No significant correlation was found between the serum and synovial IGFBP-3 of the L4 patients or OA patients with age and disease duration. Moreover, no significant difference was ,found between-IGFBP-3 level in serum and synovial .fluid of seropositive RA patients when compared to seronegative RA patients. A significant negative correlation (P < 0.01) was found between serum IGFBP-3 of RA patients and the hemoglobin concentration, also between serum and synoviar 1GFBP-3 in OA patients. From this study, we concluded that in RA, there may be a role of IGFBP-3 in impairing the cartilage repair by decreasing the bioavailability of IGF-1. However it is not the only inducer of cartilage destruction. On the other hand, IGFBP-3 is not the primejactor inhibiting cartilage repair in OA. The physiological significance of IGFBP-3 and the proteolytic enzyme activity is still unclear. The regulatory role of the IGF-1, its binding protein and the protease system is yet to be characterized

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