DIAGNOSTIC VALUE OF GRANULOCYTE COLONY STIMULATING FACTOR IN NEWBORN WilTH SEPSIS
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Bacterial sepsis is a major cause of morbidity and mortality in neonates. Granulocyte colony stimulating factor (G-CSF) is a physiologic regulator of neutrophil production and function. The aim of this study was to determine if serum granulocyte colony stimulating factor level could be of value in diagnosing neonatal sepsis. We measured serum G-CSF levels by enzyme linked immunoassay in 70 newborn infants of varying gestational ages and postnatal ages. We classified the infants into 3 groups: group I (18 infants) with positive bacterial blood culture result; group 11 (25 infants) with negative blood culture result but evidence of clinical sepsis, and group III (27 infants) with negative blood culture and no evidence of infection (control group). The mean G-CSF level was 2312 ± 396 pg/ml in group I, 2173 ± 415 pg/ml in group II, and 166 ± 19 pg/ml in group III . The mean G-CSF levels of group I and ll were significantly higher (P<0.05) than those of group III. G-CSF levels were positively correlated with the higher number of risk factors and HSS in groups I and II. On the basis of cut off value 204 pg/ml, the sensitivity of G-CSF was 94% and specificity was 74%. Thus we concluded that G-CSF levels represent a sensitive marker of infection in neonates of varying gestational ages.