The pathogenesis of ovarian dysfunction was studied in ten
female patients with chronic renal failure treated with regular
hemodialysis. Their ages ranged 20 - 37 years. Another ten
healthy adult females served as controls, their ages ranged 23 to
35 years. Assessment of follicle stimulating hormone (FSH),
luteinizing hormone (LH), prolactin and estradiol (E.)) in serum
was done. Clomiphene stimulation test to FSH and CH was also
done in a random group of 7 dialyzed patients. Serum FSH, LFI
and (E2) in dialyzed patients were comparable to those found in
normal women during the follicular phase of the menstrual cycle.
In all patients. there was an absence of cyclicity. After
elomiphene, serum levels of LH and FSH rose significantly
suggesting that the negative El feedback, the tonic gonadotropin
secretion and the pituitary ovarian axis were normal. The positive
E2 feedback associated with cyclic release of LH was impaired as
indicated by the prevalence of acyclicity and absence of ovulation.
Hyperprolactinernia in dialyzed group may inhiht ovarian function
at multiple levels along hypothalamic pituitary ovarian axis. |
