SERUM LP (a) LIPOPROTEIN CONCENTRATION IN TYPE I DIABETES WITH MICROALBUMINURIA
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This study included forty subjects and they were classified into: ten healthy normal subjects as controls, fifteen insulin dependent diabetic patients without microalbuminuria and fifteen insulin dependent diabetic patients with microalbuminuria. Patients and controls were of approximately the same age. Serum total cholesterol, HDI,c. LDI,c. VLDLc, triglycerides and LP (a) were estimated in this study to find out the relation between lipoproteins including LP (a) and diabetic nephropathy. The mean serum triglycerides and VI DI c were significantly higher (P41.05) in diabetic patients with microalbuminuria compared to diabetic patients without microalbuminuria or to control group. The mean serum LP (a) level in diabetics without microalbuminuria was significantly higher (P<0.05) than that of the control group. Moreoser, the mean serum I,P (a) level in diabetics with microalbuminuria was significantly higher than the controls (P40.05) or diabetics without microalbuminuria (P<0.05). There was significant positive correlation between serum LP (a) and fasting serum glucose, postprandial glucose, total cholesterol and LDLc in diabetics with and without microalbuminuria. Elevated levels of LP (a) can be used as a marker for the development of diabetic nephropathy as it increases in patients with IDDM without microalbuminuria more than the controls. Moreover , higher levels were detected in microalbuminuric patients inspite of good control of the diabetic state.