EFFECT OF LITHIUM ON SOME NEUROTRANSMITTERS OF BRAIN TISSUE HOMOGENATE IN RATS
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Oral administration of lithium carbonate to normal rats in a dose (15 mg./animal/day) only one dose for one day (group H) and for 4 weeks (group 111) resulted in a significant decrease in some neurotransmitters (dopamine, noradrenaline, and GABA) and their precursor acids (phenylalanine, tyrosine, and glutamic acid) in rat brain tissue homogenate. However, a significant increase in serotonin concentration with a significant decrease in its precursor amino acid (tryptophan) were also observed. These biochemical changes may be of value in explaining the antidepressant effect of the drug.