SERUM OSTEOCALCIN AS A MARKER OF BONE DYNAMICS IN TIIE ELDERLY
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This study was a trial to evaluate die potential value of SCIIIIII osteocalcirt (BOP) as a marker of bone turnover in elderly osteoNrotic rink patients and to assess bone dynamics in elderly males via estimation of serum osteocalein.* Forty-five cases all were males. (15 middle aged normal control cases, 15 elderly non-osteoporotic males and 15 males with senile osteoporosis) comprised the material of this study. t For each case of this study: full history, complete clinical examination laboratory investigations(in. eluded blood picture, stool and urine analysis, blood sugar estimation, renal. and liver profile) for exclusion of any underlying disease, radiologic study (X-ray spine) and estimation of scrum calcium, phosphorus, alkaline phosphatase and serum osteocalcin, all were done. Scrum osteocalcin (BOP) was measured by the radioimmunoassay technique. Scrum calcium and phosphorus were normal in all subjects of this study. The study revealed that both serum alkaline phosphatase levels and also, scrum osteocalcin levels increased with age, and the increase for these two parameters was higher in the osteoporotic patients. Alsoaieowixonv Nip:irk:int cur relation between serum alkaline phosphatase iii the chleilv grotip‘. We found that serum osteocalcin in the first grout Cases was 3.824,0.8 hg/nil and in the second group was 7.13±1.7 ml while it was 13.40.1:33 militil in the osteoporotie group. We may conclude that serial measurements of serum osteocalcin in elderly individuals may be helpful in study of their hone dynamics and early diagnosis of senile osteoporosis.