A TOPICAL CARBONIC ANHYDRASE INHIBITOR: DORZOLAMIDE HYDROCHLORIDE 2% IN PROPHYLAXIS OF INTRAOCULAR PRESSURE RISE AFTER YAG-LASER POSTERIOR CAPSULOTOMY
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Thirty two pseudophakic eyes of 32 patients undergoing Neodymium- YAG laser posterior capsulotomy (YPC) were randomly assigned to receive either dorzolamicle hydrochloride eye drops 2% (group A) or normal saline (group B) one hour before and one hour after laser procedure then every 8 hours for 24 hours. At /,2,3, and 24 hours after YPC, the mean changes in intraocular pressure (TOP) from base line in dorzolamide treated eyes (+0. 6, +0.8, +1.5 &-1.3 mmHg), were significantly less than saline treated eyes (+3.7, +6.6, +8.9& +2.6 mmHg). The maximum rise in intraocular pressure (TOP) was observed in both groups 3 hours after YPC. A rise of 5mm Hg or more was recorded in 12.5% of eyes of group A versus 62.5% in eyes of group B (P< 0.0001) while a rise of 10mrn Hg or more was not observed in eyes of group A versus 37.5% in eyes of group B < 0.001). It was found that prophylactic treatment with dorwlamide hydrochloride eye drops 2% was significantly effective in preventing marked MP elevations following YAG laser posterior capsulotomy.