Publications of Faculty of Medicine:Postoperative Mitomycin C Can It Replace Intraoperative Application?: Abstract

Postoperative Mitomycin C Can It Replace Intraoperative Application?
Full paper Not Available

Background : Mitomycin C (MMC) inhibits the proliferation of subconlunchval fibroblasts in a dose dependent way. This leads to prevention of scar formation after glaucoma filtering surgery This scar prevention is a desirable effect in trabeculectomy surgery to increase the success rah particularly in eyes with poor surgical prognosis.17- 2) However, the use of MMC is associated with side effects.3 In attempt to htrate the effects of MMC investigators have varied the application technique including concentration of MMC, duration and site of application as well as sponge type and size. (4 - Postoperative transconjunctival application of mitomynn C has been reported to have the main ii/vantage of using low concentration with efficacy and to decrease the adverse effects and postoperative complications known to occur with the intraoperative application. ( 1) Purpose : To evaluate if there is any difference between the effects of Mitomycin C (MM C) applied postoperatively in glaucoma surgery in contrast to the rationale of intraoperative application.