EFFECTS OF VITAMIN E ON LIVER OF RATS WITH EXPERIMENTAL HYPERTHYROIDISM
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effects of vitamin E on these changes. The animals were designated as control group (group I), 3, 3', 5- Trtiodo —Thyronin (T3) injected group (group II) and T3+ vitamin E injected group (group III). At the end of the study, tissue specimens were examined for changes in structure in the T3 injected group, dilatation in sinusoids and pale cytoplasm were observed, as well as increased Kupffer cells and an increased amount of glycogen. In T3 +vitamin E injected group the amount of glycogen was similar to the control .On electron microscopic examination the mitochondria of T3 injected group were slightly larger than those of the control group. In T3 +vitamin E injected group enlargement in the spaces of Disse, increased lipid vacuoles of Ito cells and increased microvilli of hepatocytes were observed. The results of this study indicate that T3 injection causes structural changes in the liver, and vitamin E has a slight protective effect on the liver of rats with hyperthyroid.