CARDIO PROTECTIVE EFFECT OF GREEN TEA EXTRACT IN OXIDATIVE STRESS INDUCED BY EXPERIMENTAL MYOCARDIAL INFARCTION IN RATS
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Background: Oxidative stress plays a major role in the biochemical and pathological changes associated with myocardial infarction. The need to identify agents with a potential for preventing such damage has assumed greet importance. In the present study, the effect of oral administration of green tea extract on oxidative stress induced by experimental myocardial infarction in rats was investigated. Materials and Methods: Green tea extracts (5 and10 mg/kg once daily) was administered orally as pretreatment for 14 days in adrenaline treated rats. Results: Oxidative stress induced cellular damage as indicated by ultrastructural changes, like disruption of myofdament and z-band architecture along with myocardial changes was less. Conclusion: We concluded that green tea extract (GTE) afforded cardioprotection by t-educing oxidative stress induced in experimental infarction of catecholamine assault.