THE TOXIC EFFECT OF CHLORPYRIFOS (AN ORGANO PHOSPHATE PESTICIDE) IN RAT NON CILIATED BRONCHIOLAR (CLARA) EPITHELIAL CELLS
|Full paper||Not Available|
chlorpyrifos (an organophosphate pesticide) on Clara cells of rat. • Chlorpyrifos was given orally by gavage to rats at dose levels of (7.5 and 12.5 mg/kg b.w./day) for 30 days. The toxic alterations in Clara cell histology were evaluated using light and electron microscope. Clara cells showed cytoplasmic vacuolization, SER swelling and formation of cytoplasmic apical blebs. Conclusion: We concluded that • chlorpyrifos causes severe injury to rat non ciliated bronchiolar (Clara) epithelial cells. Generally the degrees ▪ of observed variations were found to be dose dependent. It could be recommended that the use of organophosphate must be controlled to avoid any hazards to the livings especially humans.