Tissue Transglutaminase Autoantibodies as Predictors of Celiac Disease and its Relationship to Histopathological Findings of Intestinal Biopsy
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Celiac disease (CD) is a common autoimmune disorder, induced by the intake of gluten proteins present in wheat, barley and rye. Previously, it was considered to be a rare childhood disorder, but is actually considered a frequent condition, present at any age, which may have multiple complications. Active CD is characterized by intestinal and/or extra-intestinal symptoms, villous atrophy and crypt hyperplasia, and strongly positive IgA anti-endomysial antibody (EMA) and tissue transglutaminase (tTG) auto-antibodies. The duodenal biopsy is considered to be the "gold standard" for diagnosis.