EFFECT OF CIPROFLOXACIN ON THE ARTICULAR CARTILAGE OF ALBINO RAT
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This study was designed to investigate the effect of ciprofloxacin, a quinolone antibacterial agent, on the articular cartilage of albino rat. Twenty five albino rats weighing 50-200 grams were classified into control and experimental animals. The experimental animals were injected subcutaneously with ciprofloxacin at 50 or 100 m/kg/day for 7 and 14 days. The control animals were injected subcutaneously with 0.5% carboxy methyl cellulose for the same periods. Following the defined duration of treatment the animals were sacrified and the articular cartilage was prepared for histological examination. Ciprofloxacin treatment at 50 or 100 mg/kg/day for 7 days resulted in degenerated cells with vacuolated and partially disintegrated cytoplasms accompanied with decreased basophilia with cavity formation. These lesions were accompanied with decrease PAS reaction and disarrangement of collagen fibers with cut fibers in the cavities or matrix defects. Rats treated for 14 day with 50 or 100 mg/kg/day ciprofloxacin demonstrated a lower incidence of lesions than rats treated for 7 days, suggesting the potential for reversibility of the toxicity during ongoing treatment.