EFFECTS OF CARBOPLATIN ON HISTOLOGICAL, HISTO CHEMICAL AND CYTOGENETICAL CHANGES IN ALBINO RAT
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Adult albino rats were treated for one week with carboplatin (40 mg/ kg body weight intraperitoneat daily) and the changes in the tubular apparat us of the kidney were investigated employing histological and enzyme- histochemz' cal methods. The effects were the following: The brush borders of the proximal tubules were stuch together and disintegrated; oedema and degeneration of cells were observed and the cytoplasm of cells showed a decrease of ATPase and non-spec& esterases. The collagen and reticular fibers were dislocated and disintegrated. Carboplatin caused significant increase in the total number of chromosomal oherrations including structural and numerical anomalies.