EVALUATION OF CIRCULATING IMMUNE COMPLEXES IN DIAGNOSIS AND FOLLOW-UP OF SCHISTOSOMIASIS
|Full paper||Not Available|
This work aims to study the role of circulating immune complexes (CICs) in serodiagnosis of active schistosomiasis and in evaluation of praziquantel efficacy. The detection of CIC by sandwich ELISA technique, using monoclonal rntibodies against schistosomal antigen diagnoses the active schistosomal infection and could be used as a more potent tool than specific antibody IgG assay in accurate serodiagnosis of schistosomiasis. The recorded increasing cure rates of Schistosoma infected mice after praziquantel treatment (39.8%, 71.6% and 91.1%, 2,6 and 10 weeks post-treatment respectively) indicate that praziquantel could be considered the milestone in treatment of schistosomiasis. The praziquantel treatment temporarly increased the CIC levels, 2 and 6 weeks post-treatment, but CIC levels decreased significantly, 10 weeks post-treatment. Specific CIC levels seem to reflect the morbidity status of schistosomiasis more than other immunological parameters and the disappearance of CIC, 10 weeks post-treatment, while schistosomal IgG antibody levels still positive could be used as a monitor of cure and evaluates drug efficacy.