EFFECT OF PRAZIQUANTEL THERAPY ON ADULT SCHISTOSOMA MANSONI WORMS
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Recent studies have demontrasted that parasite antigens in the surface membrane of adult Schistosoma worms become exposed after praziquantel (PZQ) treatment. More recently, unexpected failure of PZQ in treatment of schistosomiasis have been reported. In the present study, indirect immunofluorescent antibody test (IFAT) was used to evaluate the changes of the immune response after treatment using PZQ to be compared with the pretreatment status. Here we were trying to have an answer to the raised question of that unexpected failure by throwing more light on the mechanism of action of PZQ. The worms recovered after 1 hour post treatment exhibited either extensive but random patches of bright fluorescence or uniform fluorescence over the entire surface of the worm. After 24 hours posttreatment the intensity of the fluorescence was lower than those of the forementioned group with statistically insignificant difference. PZQ was found, in the present study, to be a very effective schistosomecidal drug. The unexpected failure of treatment might be due to either host, parasite or environmental factors.