A STUDY ON A CHEMICALLY MODIFIED ANTIGEN (VACCINE) AGAINST TOXOPLASMOSIS
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The development of a vaccine to bring toxoplasmosis under control has been the aim of many investigators allover the world. This study was designed to test the effect of a new vaccine derived from chemically modified Toxoplasma antigen. There was direct effect of the vaccine on fresh Toxoplasma cyst wall. Stained blood pictures of infected then vaccinated mice (group III) showed 11000 immune cells/ml, that was more than that of vaccinated then infected mice in group IV (5000 immune cells/ml). Humoral immune response, determined by measuring IgM titre was higher also at group III (0.376 th 0.290) than at group IV (0.283 th 0.082). This immune response may be the cause of direct stoppage of death rate of mice at group III and long life to the end of the experiment and shorter survival days for mice at group IV. Lastly, these effects were assured by histopathological studies that showed repair of the pathological changes caused by Toxoplasma infection in group III after vaccination. Results suggest a possible curative effect with slight prophylactic effect of that tested vaccine.