IMMUNOLOGICAL EFFECTS OF NHN VACCINE, A CHEMICALLY MODIFIED BIOMPHALARIA ALEXANDRINA SNAIL ANTIGEN
|Full paper||Not Available|
The development of a vaccine that brings schistosomiasis under immunological control has been the goal of many investigators all over the world for decades. This study was designed to test the effects of NHN vaccine which contains chemically modified Biomphalaria Alexandrina Snail antigen on reducing the worm burden, inducing body immune re-Sponse through raising the IgG titre and on reducing the incidence of pathological changes in organs from mice vaccinated then infected compared to mice infected without vaccination (prophylactic effect) and also in mice infected then vaccinated (curative effect). Statistical analysis of the results showed that NHN dose-dependantly raised the IgG titre in the vaccinated mice. 2 The number of worms recovered from mice pre-injected with the vaccine then challenged with schistosomal cercaria was about 10% of the number recovered from mice challenged without prevaccination. Vaccination with NHN significantly reduced the incidence of pathological changes in livers and intestines in challenged mice. These results suggest a possible potent effect of the compound tested (NHN vaccine) in preventing and even curing the pathological consequences of schistosomiasis infection.