EFFECT OF COLCHICINE ON HEPATIC FIBROSIS IN EXPERIMENTAL SCHISTOSOMIASIS
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Swiss albino mice infected with Schistosoma rnansoni were treated with praziquantel and colchicine either separately or combinedLiver specimens were examined for granuloma number, size and degree of fibrosis in treated and un- treated mice. Colchicine therapy alone or combined with praziquantel was associated with a reduction in the degree of hepatic fibrosis. The maximum antifibrogenic effect in all groups was achieved by combined therapy of praziquental and colchieine when given early (8 weeks) during infection. However, the antifibrogenic effect was still noticed with therapy given relatively later(i.el2weeks) after infection. It was concluded that colchicine reduces hepatic fibrosis induced by chistosoma mansoni infection especially when given early with the antift schistosomal thcrapyipraziquantel.