Atopic Dermatitis: Role of Langerhans Cells
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Tissue from non-infected eruption offifty AD subjects, non-lesional skin of 10 patients and from nonnal skin of 10 healthy persons was subjected to direct inununofluorescence technique using fluorescein isothiocyanate Labelled antiserum specific for IgE and indirect immunofluorescence technique using monoclonal antibodies, IgE was detected in the lesional skin of 88% of cases in both epidermis and dermis. T-helper cells were present in all biopsies from lesional skin while T-suppressor cells were present in fewer num-ber of biopsies. Langerhans cells (LCs) were found in all biopsies from lesional skin of AD patients. This study suggests that IgE mediated type IV hypersensitivity may be implicated in the aetiology of atopic dermatitis.