Publications of Faculty of Medicine:CD4, CD8 and CD4/CD8 Ratio in HTV Infected Individuals With and Without Cutaneous Manifestations: Abstract

CD4, CD8 and CD4/CD8 Ratio in HTV Infected Individuals With and Without Cutaneous Manifestations
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Infection with the human immunodeficiency virus (HIV) results in progressive depletion of the CD4 subset T-lymphocytes and the devel opment of skin opportunistic infections, in flammatory dermatoses and unusual malig nancies. Both clinical and immunological evaluation were done for 23 HIV infected pa tients and 20 individuals with negative HIV. They were classified into four categories ac cording to the CD4 percentage: a)Group I (control group) with HIV nega tive, CD4 percentage (50.18%). b)Group II HIV infected patients without any clinical manifestations, CD4 percentage (33.51%). c)Group III HIV infected patients with re current oral candidiasis, CD4 percentage (20.26%). . d)Group IV HIV infected patients with other cutaneous manifestations (Molluscum contagiosum, Onychomycosis, Herpes zoster, Acneform eruption, Seborrheic dermatitis, psoriasis and Kaposi's sarcoma) CD4 per centage (12.19%). Improved understanding and recognition of the clinical spectrum of the skin manifesta tions of HIV patients and its relation to the immunological state will lead to improved pa tient care since early identification and treat ment can be achieved more readily.The human immunodeficiency virus produc es progressive immunodeficiency (depletion of the CD4 subset T lymphocytes) that results in many opportunistic infections as well as several papulosquamous or inflammatory cutaneous disorders and unusual malignancies'2'. There is a definitive relationship between the level of immunocompetence and these disorders'3'. By recognizing the cutaneous manifestations, the dermatologist can suspect or possibly define and diagnose HIV infection early in its course. In these patients, skin diseases even common ones, may appear quite different from what is usually seen in immunocompetent persons'4' yet undefined cofactors. Many studies have con firmed a median progression time of about 10 years although substantial individual variability exists'5'. Other studies have found that timely intervention, i.e. antiretroviral therapy and/or primary prophylaxis for the most common op portunistic infections can significantly delay the •"development of AIDS, and affect over all mor bidity and mortality'6'7'.