Publications of Faculty of Medicine:Evaluation of biomarkers of oxidant-antioxidant balance in patientswith acne vulgaris: Abstract

Evaluation of biomarkers of oxidant-antioxidant balance in patientswith acne vulgaris
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There have been controversial arguments and conflicting research results on whether oxidaiive stress plays a role in the etiopathbgenesis of acne vulgaris, or rt is just a consequence of the disease. Objectives The aim of this study was to explore the effect of oxtdative stress burden, mainly lipid; perowdation, on the oxidant-antioxidant balance and on the development of acne by studying the activity pf some oxidative stress markers^ - Patients and methods; This studywas conducted on 40 acne vulgaris patients and 36 age-matched and sexmatched heahhy controls. Patients were classified into mild, moderate, severe, and very severe on ihe basis of the GlobalAcne Grading System. Venous blood samples taken from both patients and controls were analyzed to determine the activity of the antioxidant enzymes: superoxide dismutase (SOD), cataiase (CAT), and glucose-6- phosphate dehydrogenase (G6P0); tile levels ofmalondiaidehyde (MDA), anrajorby product and an importantmarker of lipid peroxidation, were also determined. ^Different^, laboratory techniques suitable for each marker Were used and the results were read spectrophotometrically. Resultsi A highly significant decrease in the mean blood G6PD, CAT, and SOD enzyme •;• : ; activities (P<0.001) and a highly significant increase in the mean MDA (P<0.001) blood levels were detected in acne patients compared with controls. None of the -• measured m^kers (G6PD, SOD,CAT, aund MDA)was found to correlatewith pat^nts' : age, disease duration, or severity (P>0.05).i Conclusion The significant decrease in the antioxidant enzyme biomarkers, as well as the significant increase in the lipid peroxidation marker, indicates the compromised , : oxidant-antioxidant balance in patientswith acne vulgaris. This justifies adding antioxidants to acne therapy and calls for finding amultibiomarker scoring system for a better evaluation and monitoring of oxidative stress and its consequences.^