Publications of Faculty of Medicine:Vitiligo and HLA System: Abstract

Vitiligo and HLA System
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The association of HLA antigens with vitjligo reimtinsa controversial issue. In order to determine ^hich, if any. HLA markers were associated with an increased risk ol vitiligo we investigated HLA antigens in 50 patients with vitiligo and in 50 con trols using the standard mierolymphocytotoxic method. Vitiligo patients had ^ignificant increase in HI.A-Aj. A,,,. \iUi CAVj DR.. and DQ; compared to controls. Familial vitiligo i> marked by increased freL|uency of HLA-Ais. [In- By. IL>. CW. and DQ-, while non- familial vitiligo is marked by increased frequenc) of HLA-A:, C\V(, and I^R|.!. These findings suggest that immunogcnelie incchanisms may be responsible for vitilteo. Also there may he heterogenecity in the pathogenic process between familial and noti- familial vitilrgo.