Objectives: The present study aimed tolestimation of tissue extract epidermal
growth factor receptor (EGFR) and serum squamou_s cell carcinoma.
antigen (SCCA) levels in patients with inverted papilloma (IP) in varied
pathological states as a trial to determine their role in pathogenesis and/
or their applicability for differentiation between these different patho/ogical
changes. •
Patients & Methods: The study included 6 cases with primarily diagnosed
IF. 4 cases with recurrent IF and 3 cases had IF with SCC and 10
healthy volunteers to give blood samples as control group. All patients underwent
full history taking. general and local examination and CT irnag- •
ing was conducted. All cases underwent endoscopical excision and freshly
excised IF tissues were divided into two parts: the first for
histopathological examination and the second was immediately frozen on
dry ice and stored in liquid nitrogen at -70°C until processed for estimationof
tissue extract level of EGFR. Venous blood samples were obtained
prior to and after surgical resection for ELISA estimation of serum SCCA.
Results: The study included 13 patients: 10 males and 3 females.
with mean age of 62.4+6.2 years. Nasal obstruction was the main presenting
symptom followed by epistcods arid headache. Patients with recurrent
IF gave history of previous endoscopic removal since a mean duration
of . 6.24-2.2 months and one patient had recurrent IF twice.
Histopathological examination documented the diagnosis of benign IP in
10 cases and SCC changes in 3 IP. Mean EGFR levels estimated in tissue
extract of IP with SCC was signOcantly higher compared to benign IF
with significantly higher levels in recurrent IF compared to primary IP.
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Ahmed S. El-Kady, et al...
Preoperative serum SCCA levels were significantly higher in patients had
IP with SCC compared to levels ik controls arid patients with benign IP
and in sera of patients had recurrent IP compared to controls and patients
had prirrianj IP. Postoperative serum SCCA levels were significantly
lower compared to preoperative levels in all patients' groups and in patients
with benign IP nearly- returned to control levels, while in patients
with cancerous changes postoperative serum SCCA levels were still signiftcantly
higher compared to control levels and non-signiftcarttly higher
compared to levels estimated in patients with benign IP.
Conclusion: EGFR tissue expression level could be used for differentiation
between benign and malignant IP even in early phases of dysplasia
and serum SCCA could be used as a marker for complete operative excision
of IP irrespective of its pathological diagnosis. |
