SOME EFFECTS OF FORMALIN INGESTION ON SURFACE GASTRO-DUODENAL EPITHLIAL CELLS OF ALBINO RATS.
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This study was performed on 80 adult male albino rats, divided into 4 equal groups. One group was kept as a control. The other 3 groups were exposed to formaldehyde in the drinking water with concentrations of 0.02, 0.1 and 0.5% (mild-, moderate- and high intake groups). Each group was subdivided into two equal subgroups, one was examined after 1 month of formalin intake and the other after 6 months. The surface gastric and duodenal vinous tip epithelial cells were isolated. The effect of fonnalin (the aqueous solution of formaldehyde) on the viability and A7Pase and succinic dehydrogenase activities of the gastric cells was found directly proportional to the dose and duration of exposure. The adverse effects on the duodenal epithelial cells were noted only with the high-dose exposure for six months. This limited effect offormalin ingestion on these cells may be due to decreased conrentration of formalin reaching the duodenum. Low-dose exposure to ibrmalin had no such effects on both types of cells.