OXIDATIVE STRESS IN DIAZINON-INDUCED ACUTE HAEMORRHAGIC PANCREATITIS
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Severe necrotizing pancreatitis may occur in humans after a subclintcal and unevenVul course of Organophosphate (OP) pesticides. This study was conducted to evaluate the role of oxidative* stress in diazinoninduced acute haemorrhagic pancreatitis. Sixty three male guinea pigs were divided into three groups; a negative control, a positive control and a test group. Acute pancreatitis was induced in animals of positive control and test groups by a sublethal dose of the organophosphate insecticide Diazinon. Acute pancreatitis was induced in test animals under umbrella of vitamin E to eliminate the effect of oxidative stress. Animals of the positive control and test groups were sacrificed 0.5, 1, 2 & 6 hours after induction of pancreatitis. Serum amylase and lipase values were measured, the gross appearance of the pancreas was noted and pancreatic tissue samples were taken for light and transmission electron microscopic study. The results suggest that the use of the antioxidants offers a protective action for partial prophylaxis against induction of acute pancreatitis by sublethal doses of Participation of oxidative stress in the pathogenesis of this DZ induced acute pancreatitis was also insinuated.