ULTRASTRUCTURAL STUDY OF THE EFFECT OF TERBINAFINE (LAMISIL) ON THE HEPATOCYTES OF ADULT ALBINO RATS
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Forty eight adult male albino rats were used in this study. They were divided into five groups; four of them (each consisted of ten rats) were given the therapeutic dose of terbinafine and the fifth (consisting of eight rats) was used as control. The first group was given the drug for Iwo weeks, the second for six weeks and the third for twelve weeks. The fourth group was given the drug for twelve weeks and left for another month without drug to test the effect of drug withdrawal. On light microscopic examination of liver specimens, vaculation of the hepatocytes, dilatation of the blood vessels and infiltration of the areas surrounding central veins and portal tracts with inflammatory cells were noticed in the first three groups. These changes increase with the duration of drug intake. Ultrastructural examination showed some changes in the mitochondria, endoplasmic reticulum, lysosomes and lipid droplets of the hepatocytes in addition to mild dilatation of the bile canaliculi. All light and electron microscopic changes disappeared after one month of drug withdrawal.