Aim: To examine P27 and MUC I protein expression in
specimens of papillary transitional cell carcinoma-urinary
bladder and to compare both of them with the tumor outcome.
Methods: Paraffin-sections from previously diagnosed
papillary transitional cell carcinoma-urinary bladder were
graded, staged and followed up for 5 years. Ten non neoplastic
urologicl lesions diagnosed as polypoid cystitis were taken
as a control. Three sections of 4 micron thickness were
obtained for every case. One is H & E stained for diagnosis
reviewing and confirmation. The other 2 sections are immunohistochemically
stained for both P27 and MUC1.
Results: The data of immunohistochemical results were
correlated with the following conventional prognostic variables:
tumor grade, stage, distant metastasis and 5-year survival of
papillary transitional cell carcinoma (PTCC)-urinary bladder.
The results showed a highly significant and an insignificant
relationships between P27 expression and tumor grade and
stage respectively (p<0.01 & >0.05). Correlating P27 expression
with distant metastasis and overall survival showed a
significant relationship with distant metastasis (p<0.05) and
a highly significant one with overall survival (pc0.01).The
results showed also a significant relationships between MUC I
expression and both tumor grade and 5-year overall survival
(p<0.05 for both).
Conclusion: In conclusion, P27 and MUC1 immunohistochemistry
may augment the classic histochemistry for
prognosis of PTCC as well as prediction of the patient outcome.
Specific oncogene markers are more significant than oncogene
phenotype markers in clinical diagnosis and screening of
PTCC.
Key Words: P27 and MUCI protein — Papillary transitional
cell carcinoma — Urinary bladder |
