Aim: To examine C-met and P27 protein levels in specimens
of invasive breast carcinomas and adjacent breast tissue
and to compare both of them with breast cancer clinical
outcome.
Methods: Paraffin-sections from previously diagnosed
breast cancer were graded, staged and followed-up for 5 years.
Ten apparently normal breast tissues near by benign breast
tumors were also used as normal control. Three sections of
4 micron thickness were obtained for every case. One is H&E
stained for diagnosis reviewing and confirmation. The other
2 sections are immunohistochemically stained for C-met and
Results: The data of immunohistochemical results were
correlated with following conventional prognostic variables:
Tumor grade, stage, distant metastasis and 5 year survial.
The results showed a significant and highly significant
relationship between c-met expression on one hand and the
tumor grade and stage on the other (p<0.05 & <0.001).
Correlating C-met expression with distant metastasis and
overall survival showed a positive highly significant relationship
with distant metastasis (p<0.01) and a negative significant
one with overall survival (p<0.05). The results showed also
a significant and highly significant relationships between p27
expression score on one hand and breast carcinoma 5-year
survival, grade and distant metastasis on the other (p<0.05,
<0.001 and 0.001respectively).
Conclusion: In conclusion, C-met and p27 could be
considered as independent prognostic factors in breast carcinoma.
In addition C-met could be a promising putative target
in breast cancer therapy. |
