Role of Cyclin E and BcI-xL in Colorectal Carcinoma: An Immunohistochemical Study.
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Aim: This study aims at assessment of the role of Cyclin E and Bc1-xL in colorectal carcinoma. Patients and Methods: This study was carried on 50 cases offormalin-fixed paraffinembedded tissues of colorectal carcinoma and ten normal control cases. They were graded and staged according to grading and 7'NM staging systems. All cases were immunohistochemically examined for Cyclin E and BcI-xL. Results: Immunohistochemical results of both Bc1-xL and Cyclin E were correlated with other clinicopathologic variables, tumor stage, grade, metastatic status and 5 year survival. The results showed a signcant relationship between Cyclin E in one side and tumor grade, metastatic status and 5-year survival in the other (P<0.5). However, statistically it showed insignificant relationship between Cyclin E immunoreactivity and tumor stage. In relation to Bc1-xL immunoreactivity, it showed a highly significant correlation with tumor stage (P < 0.01) and a significant relationship with metastatic status and 5-year survival. However, no significant relationship between Bc1-xL and tumor grade could be detected. Conclusion: Cyclin E overexpression could be considered as a tumorigenic factor in the pathogenesis of colorectal carcinoma. It could be considered as one of the prognostic factors of colorectal carcinoma. Also BcI-xL may have a role in the pathogenesis of colorectal carcinoma and is associated with tumor progression and poor prognosis. However, the precise mechanism of Bc1-xL underlying the carcinogenesis of human colorectal carcinoma is still unclear, and further studies may be needed