Sixty eight cases of soft tissue sarcoma (Sib) selected from the files of
Pathology Departments, Bertha Faculty of Medicine-ZagazigUniversity
and National Cairo Institute- Cairo University, during the period from
1993 to 1997, were examined by light microscopy and classified into 44
differentiated cases (64.7%) and 24 undfferentiated cases (35.3%). The
differentiated cases were studied by histocheoical and immunohistochemical
stains using a panel of Antibodies. We applied the results of histological,
histochemkal and immunohistochemical reactivity of classified
cases -on the 24 undifferentiated cases in trial to classify them.. Histochemical
and immunohistochemical stains were of most value in classification
of 18 (75%) out of 24 undWerentiated cases as: 4 cases liposarcoma,
4 malignant fibrous histiocytoma (MFH). 4 leiomyosarcoma, 2
angiosarcoma, one case of monophasic synovial sarcoma and 3 cases of
rhabdomyosarcoma. Combination of electron microscopic (E.M.) with light
microscopic examination, (L.M), his tochemical and immunohistochemical
stains resulted in a specific diagnosis in 4 out of 6 unclassified cases
(66.7%). This work supports the view that LM. readily discriminate between
differentiated tumor types. Special histochemical stains could be
supportive and confirmatory. Irnmurtohistochemical markers together with
appropriate clinical and histological features can minimize the number of
undifferentiated sarcomas. In problematic cases. immunohistochemical
and E.M. have complementary role.
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Hata A. Agina et al . |
